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Last Updated: Dec 2025

Best Weight Loss Medications of 2025

Explore top-rated weight loss treatments and access tirzepatide or semaglutide medications, designed to help you manage your weight effectively.

Reviewed by
Emilia Baran
, M.D.
Clinical Researcher
Emilia Baran, M.D., is a physician with a diverse clinical and research background and has contributed to both academic and community health settings. Dr. Baran volunteers at health clinics, works as a fact-checker for HealthDay News, and participates in multiple clinical research projects.
Clinical Researcher
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Our Top Pick for Weight Loss Injections
FAQs – Weight Loss Medications
What is weight loss medication?
These are prescription treatments that help manage appetite, regulate blood sugar, and support digestion, as part of a comprehensive weight loss plan.
What is the best weight loss medication available today?
GLP-1 medications like Tirzepatide and Semaglutide are among the most effective options available today. Your provider will recommend the best Tirzepatide or other solution based on your unique needs.
Are compounded weight loss medications safe?
Yes, when they’re prepared by licensed U.S. compounding pharmacies and prescribed following a medical evaluation, they offer a safe and personalized alternative.
How do compounded medications compare to brand-name versions?
Compounded medications use the same active ingredients as brand-name drugs—like in a Tirzepatide compound—while often offering greater affordability.
Do I need a prescription for weight loss medication?
Yes. A licensed provider must evaluate your health and goals before prescribing any weight loss treatment.
Is there a personalized medical evaluation?
Absolutely. Every treatment plan starts with a medical review to ensure that your chosen medication—whether Semaglutide, Tirzepatide, or a Tirzepatide compound—is safe and well-suited for you.

*Subject to RemedyMeds Terms of Service.

**Subject to Ro Terms of Service.

Understanding Weight Loss Medications

Weight loss medications are a modern, medically supported way to help people lose excess weight. Unlike traditional programs that rely only on diet and exercise, these treatments offer added support by:

  • Curbing appetite

  • Boosting metabolism

  • Promoting fat loss

They’re especially helpful for people who have struggled to see results with diet and exercise alone.

How Do These Medications Work?

Weight loss medications work by interacting with the body’s natural hormones to help regulate hunger and energy use.
One of the most common medications is semaglutide, found in brands like:

  • Ozempic®

  • Wegovy®

This drug mimics GLP-1, a hormone that:

  • Reduces appetite

  • Increases the feeling of fullness

  • Supports insulin function

The result? Eating less and feeling satisfied with smaller portions.

Types of Weight Loss Medications

There are several types of medications designed to support weight loss, including:

  • Semaglutide (Ozempic®, Wegovy®)

  • Liraglutide (Saxenda®)

  • Phentermine-topiramate (Qsymia®)

Each has a slightly different way of working, but all help by reducing appetite, increasing satiety, or improving metabolism.

Benefits of Weight Loss Medications

Beyond weight loss, these medications may lead to:

  • Improved blood sugar control

  • Lower risk of heart disease

  • Increased mobility

  • Better quality of life

  • A more sustainable approach than relying on willpower alone

How to Get Started

Getting weight loss medication typically involves:

  1. Consultation with a licensed healthcare provider

  2. Evaluation of your health history and weight loss goals

  3. Prescription for the most suitable medication

  4. Access through a pharmacy or medical provider (in person or via telehealth)

Many platforms now make it easy to get started from home.

What to Expect from Treatment

  • Most people begin to see changes within a few weeks

  • Results depend on how closely you follow your treatment plan and lifestyle choices

  • Regular check-ins with your provider are key for tracking progress and adjusting your care


Disclaimer: This content was generated with AI, along with human verification.

Disclosures:

  • Top10 does not provide medical advice, diagnosis, or treatment or provide or dispense medical products. If you think you may have a medical emergency, call your doctor or your local emergency number immediately.
  • In certain instances, your healthcare provider may suggest compounded medications as an alternative to FDA-approved options. These compounded medications are formulated by a state-licensed sterile compounding pharmacy. It is important to understand that while federal law allows the prescription of compounded drugs, they are not FDA-approved and do not receive the same level of review for safety, efficacy, or manufacturing standards.
  • The statements above about drug products have been provided by the Service; Top10 makes no representation about and assumes no responsibility for these statements.

(*)The assessment made available on the Remedy Meds website does not create a doctor-patient relationship between the individual completing the assessment and Remedy Meds. Remedy Meds is not a provider of medical services. Remedy Meds acts primarily as a technology platform to connect you with professional healthcare providers who may be available to provide you with non-emergency care. Such providers include JMP Medical, OpenLoop Health, and certain other medical groups (collectively, the “Providers”). The Providers include a network of US-licensed doctors that adhere to rigorous medical protocols designed for patient safety and have established exclusionary criteria to determine if an individual does not qualify for GLP-1s. Each Remedy Meds assessment will be reviewed by a Provider who will determine if the individual is eligible for GLP-1 medication and qualifies for a prescription. Provider clinicians retain the decision to prescribe compounded GLP-1s to patients.

All claims and benefits on this website refer to self-reported data from Remedy Meds customers on a treatment plan that includes compounded GLP-1 medications and consultations with medical professionals. Customers reported their weight on their initial medical intake questionnaire every 3-4 weeks thereafter. Results from compounded medications found on the Remedy Meds platform may vary and be affected by an individual's adherence to the program and their clinician's recommendations. Compounded GLP-1s are produced in FDA-regulated facilities. Although these facilities are highly regulated, the medications are not FDA-approved or evaluated for safety, efficacy, or quality. The decision to use compounded drugs is guided by the licensed provider's medical judgment, which is informed by a telehealth consultation and medical history.

We encourage all prospective users of compounded medications to speak with their provider about the specific risks and benefits that may come with the use of compounded medication. Remedy Meds does not produce compounded medications, and individuals may receive medication that looks different than what is portrayed on the website.

(**)Along with a reduced calorie diet and increased exercise. In a 68-week clinical study of Wegovy®, about 1 in 3 adults with obesity or with overweight and weight-related medical problems achieved 20% weight loss. Average weight loss achieved was 15%. Wegovy® is a registered trademark of Novo Nordisk A/S. Hims, Inc. is not affiliated with or endorsed by Novo Nordisk A/S.

Our Top 3 Weight Loss Treatments

  • 1
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    Description

    RO provides a convenient way to access Semaglutide (GLP-1) weight loss treatments, including Zepbound®, Wegovy®, and compounded options. Designed for adults with a BMI ≥27, these medications help reduce appetite and improve metabolic health when combined with diet and exercise. With pricing starting at $399/month, RO offers a telehealth-first approach to weight management, making medically supervised treatments more accessible.

    Read RO Review
    Pros & Cons

    RO Pros & Cons

    PROS

    Convenient online doctor consultations
    Multiple treatment options, including Zepbound®
    Insurance coverage & paperwork handled

    CONS

    Limited insurance coverage options
    Availability of certain medications may vary
    RO
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  • 2
    • Oral and injectable GLP-1 medications including Ozempic® starting at $179
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    Description

    MEDVi offers doctor-prescribed GLP-1 treatments like Semaglutide and Tirzepatide to support weight loss by curbing appetite and boosting metabolism. Starting at $179/month, this telehealth program provides a convenient, medically supervised option.

    Read MEDVi Review
    Pros & Cons

    MEDVi Pros & Cons

    PROS

    Transparent pricing with medication costs included
    Multiple treatments, including Semaglutide & Tirzepatide
    Affordable options for compounded medications

    CONS

    Availability of certain medications may vary
    Prescriptions are cash-pay
  • 3
    • Access Ozempic®, Wegovy®, Zepbound®, and other GLP-1s starting from $199/mo
    • 100% online doctor visits and prescriptions
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    SkinnyRX Pros & Cons

    PROS

    Compounded oral GLP-1 tablets available for non-injection use
    Personalized plans by board-certified doctors
    U.S.-dispensed medication from licensed pharmacies

    CONS

    Compounded drugs are not FDA-approved
    BBB rating B and not accredited